ELECTROCHEMICAL REDUCTION OF METRONIDAZOLE AT ACTIVATED GLASSY-CARBONELECTRODE AND ITS DETERMINATION IN PHARMACEUTICAL DOSAGE FORMS

A voltammetric method has been developed for the determination of metr onidazole in dosage forms. The method is based on the electrochemical reduction of the drug at a glassy carbon electrode activated by applyi ng a new pretreatment. The influence of pH, concentration, scan rate a nd presence of organic solvent and surfactant has been studied. The cu rrent is proportional to the concentration and permits the drug to be determined in the concentration range 2 x 10(-6)-6 x 10(-4) M in Britt on-Robinson buffer (pH 10). Furthermore, results obtained by the propo sed method have been compared with USP XXIII procedure which involves a HPLC method. (C) 1998 Elsevier Science B.V. All rights reserved.