THE GROWTH-HORMONE RESPONSE TO BACLOFEN IN OBSESSIVE-COMPULSIVE DISORDER - DOES THE GABA-B RECEPTOR MEDIATE OBSESSIVE ANXIETY

Authors
LUCEY JV BUTCHER G OFLYNN K CLARE AW DINAN G
Citation
Jv. Lucey et al., THE GROWTH-HORMONE RESPONSE TO BACLOFEN IN OBSESSIVE-COMPULSIVE DISORDER - DOES THE GABA-B RECEPTOR MEDIATE OBSESSIVE ANXIETY, Pharmacopsychiatry, 27(1), 1994, pp. 23-26
Citations number
33
Categorie Soggetti
Psychiatry,"Pharmacology & Pharmacy
Journal title
Pharmacopsychiatry → ACNP
ISSN journal
01763679
Volume
27
Issue
1
Year of publication
1994
Pages
23 - 26
Database
ISI
SICI code
0176-3679(1994)27:1<23:TGRTBI>2.0.ZU;2-G
Abstract
The growth hormone (GH) response to the gamma amino butyric acid type B (GABA-B) receptor agonist baclofen was measured in 10 Caucasian out- patients with DSM-III-R obsessive compulsive disorder (OCD) and 10 hea lthy comparison subjects. The patients also underwent a dexamethasone suppression test. The GH response was similar in both groups and there was a low rate of dexamethasone non-suppression in the patients. The data do not suggest that GABA-B receptor dysfunction is a feature of o bsessive anxiety.