DIFFERENTIATION BETWEEN TRANSMURAL PERIOPERATIVE MYOCARDIAL-INFARCTION AND SUBENDOCARDIAL INJURY AFTER CORONARY-ARTERY BYPASS-GRAFTING USING BIOCHEMICAL TESTS, ELABORATED BY CLUSTER AND DISCRIMINANT-ANALYSIS
Ga. Harff et al., DIFFERENTIATION BETWEEN TRANSMURAL PERIOPERATIVE MYOCARDIAL-INFARCTION AND SUBENDOCARDIAL INJURY AFTER CORONARY-ARTERY BYPASS-GRAFTING USING BIOCHEMICAL TESTS, ELABORATED BY CLUSTER AND DISCRIMINANT-ANALYSIS, Clinica chimica acta, 274(1), 1998, pp. 29-40
The aim of this study is to differentiate between transmural periopera
tive myocardial infarction (T-PMI) and subendocardial perioperative my
ocardial injury (S-PMI) as a complication of coronary artery bypass gr
afting (CABG). Seventy-three patients undergoing CABG were followed po
st operatively by measuring troponin T, CK-MB isoenzyme mass concentra
tion (CK-MB mass), creatine kinase MB isoenzyme activity (CK-MB activi
ty), creatine kinase (CK), alpha hydroxybutyrate dehydrogenase (HBD),
and aspartate aminotransferase (AST) at five sampling times. Lacking a
proper definition of the gold standard for the diagnosis of periopera
tive myocardial infarction, a statistical procedure was used. Supporte
d by the cluster analysis method of Ward, patients were assigned to a
patient group with a perioperative myocardial infarction (PMI) or a pa
tient group without a PMI (non-PMI) as a confirmation of interpretatio
n of the biochemical results, Using the results of electrocardiogram (
ECG) and echocardiography, the PMI patient group was split into a T-PM
I patient group and a S-PMI patient group. With discriminant analysis,
two canonic discriminant functions were drawn up to differentiate bet
ween patients suffering from a T-PMI or S-PMI and non-PMI patients. (C
) 1998 Elsevier Science B.V. All rights reserved.