PEPTIDYL BETA-HOMO-ASPARTALS - SPECIFIC INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME AND ITS HOMOLOGS (CASPASES)

Authors
BAJUSZ S FAUSZT I NEMETH K BARABAS E JUHASZ A PATTHY M
Citation
S. Bajusz et al., PEPTIDYL BETA-HOMO-ASPARTALS - SPECIFIC INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME AND ITS HOMOLOGS (CASPASES), Bioorganic & medicinal chemistry letters, 8(12), 1998, pp. 1477-1482
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
12
Year of publication
1998
Pages
1477 - 1482
Database
ISI
SICI code
0960-894X(1998)8:12<1477:PB-SIO>2.0.ZU;2-G
Abstract
Inhibition of interleukin-1 beta converting enzyme (ICE), apopain, pap ain, thrombin and trypsin with substrate like peptidyl L- and D-alpha- aldehydes and their L-beta-homo-aldehyde analogues was investigated. T he L-beta-homo-aspartals appear to be specific inhibitors for ICE and its homologues; the other enzymes were not inhibited with such L-beta- homo aldehydes. Papain shows tolerance for D-residues at P-1 depending on their chiral stability. (C) 1998 Elsevier Science Ltd. All rights reserved.