SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF 13-DEHYDRO DERIVATIVES OFPRIMARY PROSTAGLANDINS

Authors
TANAMI T KAMEO K ONO N NAKAGAWA T ANNOU S TSUBOI M TANI K OKAMOTO S SATO F
Citation
T. Tanami et al., SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF 13-DEHYDRO DERIVATIVES OFPRIMARY PROSTAGLANDINS, Bioorganic & medicinal chemistry letters, 8(12), 1998, pp. 1507-1510
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
12
Year of publication
1998
Pages
1507 - 1510
Database
ISI
SICI code
0960-894X(1998)8:12<1507:SAPAO1>2.0.ZU;2-G
Abstract
13-Dehydro derivatives of prostaglandin E-1, E-2, E-3, F-1 alpha, and F-2 alpha were synthesized. Compared with natural prostaglandins, 13-d ehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isola ted trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum. (C) 1998 Elsevier Science Ltd. All rights r eserved.