SYNTHESIS AND IN-VITRO CYTOTOXICITY OF LIPOPHILIC PLATINUM(II) COMPLEXES

A number of lipophilic platinum(II) complexes of the general structure s cis-[Pt(LA)(2)Cl-2] and [Pt(LD)Cl-2] were synthesised. Long chain am ines (LA) and diamines (LD), prepared from lipidic amino acids, were u sed as ligands. The in vitro cytotoxicity of the complexes was evaluat ed against four cell lines (P388, NSCLC-N6, E39, M96). cis-Dichloro-bi s(2-aminohexadecanol)platinum(II) was the most active against P388, NS CLC-N6 and E39 (IC50: 11 mu g/ml, 25 mu g/ml, 31 mu g/ml), while dichl oro(1,3-heptadecanediamine)platinum presented the highest activity aga inst M96 (IC50: 13 mu g/ml). (C) 1998 Elsevier Science Ltd. All rights reserved.