A NEW CLASS OF SULFOXIDE SURFACTANTS DERIVED FROM TRIS - SYNTHESIS AND PRELIMINARY ASSESSMENTS OF THEIR PROPERTIES

Authors
BARTHELEMY P MAURIZIS JC LACOMBE JM PUCCI B
Citation
P. Barthelemy et al., A NEW CLASS OF SULFOXIDE SURFACTANTS DERIVED FROM TRIS - SYNTHESIS AND PRELIMINARY ASSESSMENTS OF THEIR PROPERTIES, Bioorganic & medicinal chemistry letters, 8(12), 1998, pp. 1559-1562
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
12
Year of publication
1998
Pages
1559 - 1562
Database
ISI
SICI code
0960-894X(1998)8:12<1559:ANCOSS>2.0.ZU;2-C
Abstract
A new class of non-ionic amphiphilic molecules suitable for biological purposes, especially extraction of membrane proteins, is reported. Su ch surfactants were prepared in two steps : addition of alkyl or fluor oalkyl mercaptan on Tris(hydroxymethyl)acrylamidomethane (THAM) deriva tives, followed by the oxydation of sulfide group in sulfoxide moiety in order to provide water solubility to the molecule. The detergent ef ficiency of these new surfactants were assayed on rat liver cells. (C) 1998 Elsevier Science Ltd. All nights reserved.