SYNTHESIS AND PRELIMINARY EVALUATION OF (S)-2-(4'-CARBOXYCUBYL)GLYCINE, A NEW SELECTIVE MGLUR1 ANTAGONIST

Authors
PELLICCIARI R COSTANTINO G GIOVAGNONI E MATTOLI L BRABET I PIN JP
Citation
R. Pellicciari et al., SYNTHESIS AND PRELIMINARY EVALUATION OF (S)-2-(4'-CARBOXYCUBYL)GLYCINE, A NEW SELECTIVE MGLUR1 ANTAGONIST, Bioorganic & medicinal chemistry letters, 8(12), 1998, pp. 1569-1574
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
12
Year of publication
1998
Pages
1569 - 1574
Database
ISI
SICI code
0960-894X(1998)8:12<1569:SAPEO(>2.0.ZU;2-R
Abstract
The synthesis and the pharmacological evaluation at metabotropic gluta mate receptors of S-2-(4'-carboxy-cubyl)glycine (ACUDA, 9) are describ ed. S-2-(4'-Carboxy-cubyl)glycine is a structurally novel group I sele ctive antagonist for mGluR1 subtype. (C) 1998 Elsevier Science Ltd. Al l rights reserved.