HISTAMINERGIC MECHANISMS IN AMYGDALOID-KINDLED SEIZURES IN RATS

The present study was undertaken to clarify the role of histaminergic neuron system on amygdaloid kindled seizures in rats. A significant de crease in histamine contents in the amygdala was observed after develo pment of amygdaloid kindling. Histidine and metoprine inhibited amygda loid kindled seizures at doses causing an increase in histamine conten ts of the brain. H-1-antagonists (diphenhydramine and chlorpheniramine ) attenuated histidine-induced inhibition of amygdaloid kindled seizur es, however no significant antagonism was observed with H-2-antagonist s (zolantidine and ranitidine). The development of amygdaloid kindling was retarded by repeated administration of histidine. These findings suggest that histaminergic mechanisms play a suppressive role in amygd aloid kindled seizures through histamine H-1-receptors. (C) 1998 Elsev ier Science B.V. All rights reserved.