A STUDY OF THE ANTITUMOR-ACTIVITY OF 4 DIBUTYLTIN(IV)-N-ARYLIDENE-ALPHA-AMINO ACID COMPLEXES

This paper reports the activity of four dibutyltin(IV)-N-arylidene-alp ha-amino acid complexes against the National Cancer Institute (NCI) pa nel of 60 cell lines. The results indicated that three of the organoti n complexes (C17H25NO3Sn, C18H27NO3Sn and C20H31NO3Sn) exhibit their h ighest cytotoxic effect on the NCI-522 (nonsmall cell lung cancer) cel l line. The fourth complex, C21H27NO3Sn, exhibits its highest cytotoxi c activity on the cell line RXF-631L (renal cancer), In general, a low to moderate cellular response was observed for all the organotin comp lexes, with at least one cell line in each subpanel of cells exhibitin g a very low growth inhibition response to all the organotin complexes , The low-responding cell lines included HOP-62 (non-small lung cancer ), DLD-1 (colon cancer), SF-539 (CNS cancer), SK-MEL-5 (melanoma), IGR OV-1 (ovarian cancer) and RPMI-8226 (leukemia), The results also indic ated that the compounds did not exhibit any significant subpanel activ ity and suggested that the compounds were not active in all the cell l ines contained in any subpanel, The low to moderate activity of these compounds across the cell lines was attributed to the presence of nitr ogen-bearing ligands which prevented the dissociation of the compound and the subsequent binding to DNA, (C) 1998 John Wiley & Sons, Ltd.