Dh. Kim et al., METABOLISM OF PUERARIN AND DAIDZIN BY HUMAN INTESTINAL BACTERIA AND THEIR RELATION TO IN-VITRO CYTOTOXICITY, Biological & pharmaceutical bulletin, 21(6), 1998, pp. 628-630
When puerarin or daidzin were incubated far 24 h with human intestinal
bacteria, two metabolites, daidzein and calycosin, were produced from
them, respectively. The metabolic time course of puerarin was as foll
ows: at an early time, puerarin was converted to daidzin, and then cal
ycosin. The metabolic time course of daidzin by human intestinal bacte
ria was also similar to that of puerarin. The in vitro cytotoxicities
of these metabolites, calycosin and daidzein, mere superior to those o
f puerarin and daidzein.