TRYPANOCIDAL EFFECTS OF CURCUMIN IN-VITRO

Authors
NOSE M KOIDE T OGIHARA Y YABU Y OHTA N
Citation
M. Nose et al., TRYPANOCIDAL EFFECTS OF CURCUMIN IN-VITRO, Biological & pharmaceutical bulletin, 21(6), 1998, pp. 643-645
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
21
Issue
6
Year of publication
1998
Pages
643 - 645
Database
ISI
SICI code
0918-6158(1998)21:6<643:TEOCI>2.0.ZU;2-X
Abstract
During the course of study searching for the antiparasitic agents from natural compounds, we found that curcumin showed cytotoxicity against African trypanosomes in vitro. The LD50 values of curcumin were 4.77/-0.91 mu M for bloodstream forms and 46.52+/-4.94 mu M for procyclic forms of Trypanosoma brucei brucei (GUTat 3.1 clone).