ALUMINUM ALTERS INTRACELLULAR CALCIUM HOMEOSTASIS IN-VITRO

Authors
GANDOLFI L STELLA MP ZAMBENEDETTI P ZATTA P
Citation
L. Gandolfi et al., ALUMINUM ALTERS INTRACELLULAR CALCIUM HOMEOSTASIS IN-VITRO, Biochimica et biophysica acta. Molecular basis of disease, 1406(3), 1998, pp. 315-320
Citations number
36
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular basis of disease → ACNP
ISSN journal
09254439
Volume
1406
Issue
3
Year of publication
1998
Pages
315 - 320
Database
ISI
SICI code
0925-4439(1998)1406:3<315:AAICHI>2.0.ZU;2-U
Abstract
The present paper reports data regarding the influence of aluminum, at micromolar concentrations, on intracellular calcium homeostasis. Al3 modifies Ca2+ uptake in the endoplasmic reticulum (ER), accelerates C a2+ release from mitochondria and strongly inhibits Ca2+-ATPase activi ty with a consequent high-level calcium accumulation inside the cell, These results suggest that Al3+ neurotoxicity may be related to an alt eration of the intracellular calcium regulatory system. (C) 1998 Elsev ier Science B.V. All rights reserved.