SYNTHESES OF 6-CARBON-SUBSTITUTED OR 8-CARBON-SUBSTITUTED 2-OXOPURINES

Authors
IWAMURA T OKAMOTO Y YOKOMOTO M SHIMIZU H HORI M KATAOKA T
Citation
T. Iwamura et al., SYNTHESES OF 6-CARBON-SUBSTITUTED OR 8-CARBON-SUBSTITUTED 2-OXOPURINES, Synthesis, (2), 1994, pp. 203-206
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
2
Year of publication
1994
Pages
203 - 206
Database
ISI
SICI code
0039-7881(1994):2<203:SO6O82>2.0.ZU;2-T
Abstract
Reaction of 3,7-dimethyl-6-methylthio-2-oxopurine (1) with Grignard re agents or organolithiums afforded 8-adducts 2, whereas the correspondi ng reaction of 3,7-dimethyl-2-oxopurine (6) gave 6-adducts 7. The addu cts 2 and 7 were converted into 8-substituted theobromines 4 and 6-sub stituted 3,7-dimethyl-2-oxopurines 8, respectively. 8-Chlorotheobromin e (5) reacted with Grignard reagents in the presence of a catalytic am ount of NiBr2(PPh(3))(2) to give 4 in good yields.