AZOALKENE ROUTE TO METHYL [2-(PHENYLMETHYL)BENZOYL]-1H-PYRROLE-3-CARBOXYLATE (FPL-64176) AND ANALOGS - SYNTHESIS OF 1-(BOC-AMINO)PYRROLE-3-CARBOXYLATES AND THEIR CONVERSION TO 1H-PYRROLES VIA 1-AMINOPYRROLES

Authors
BAXTER AJG FUHER J TEAGUE SJ
Citation
Ajg. Baxter et al., AZOALKENE ROUTE TO METHYL [2-(PHENYLMETHYL)BENZOYL]-1H-PYRROLE-3-CARBOXYLATE (FPL-64176) AND ANALOGS - SYNTHESIS OF 1-(BOC-AMINO)PYRROLE-3-CARBOXYLATES AND THEIR CONVERSION TO 1H-PYRROLES VIA 1-AMINOPYRROLES, Synthesis, (2), 1994, pp. 207-211
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
2
Year of publication
1994
Pages
207 - 211
Database
ISI
SICI code
0039-7881(1994):2<207:ARTM[>2.0.ZU;2-I
Abstract
A new route to the calcium channel activator methyl phenylmethyl)benzo yl]-1H-pyrrole-3-carboxylate(FPL 64176) and analogues is presented. Re action of activated diones with BOC-azoalkenes gave pyrroles with the required functionality but having an extra 1-(BOC-amino) substituent. This group was readily removed in two steps to give the required 1H-py rroles.