AZOALKENE ROUTE TO METHYL [2-(PHENYLMETHYL)BENZOYL]-1H-PYRROLE-3-CARBOXYLATE (FPL-64176) AND ANALOGS - SYNTHESIS OF 1-(BOC-AMINO)PYRROLE-3-CARBOXYLATES AND THEIR CONVERSION TO 1H-PYRROLES VIA 1-AMINOPYRROLES
Ajg. Baxter et al., AZOALKENE ROUTE TO METHYL [2-(PHENYLMETHYL)BENZOYL]-1H-PYRROLE-3-CARBOXYLATE (FPL-64176) AND ANALOGS - SYNTHESIS OF 1-(BOC-AMINO)PYRROLE-3-CARBOXYLATES AND THEIR CONVERSION TO 1H-PYRROLES VIA 1-AMINOPYRROLES, Synthesis, (2), 1994, pp. 207-211
A new route to the calcium channel activator methyl phenylmethyl)benzo
yl]-1H-pyrrole-3-carboxylate(FPL 64176) and analogues is presented. Re
action of activated diones with BOC-azoalkenes gave pyrroles with the
required functionality but having an extra 1-(BOC-amino) substituent.
This group was readily removed in two steps to give the required 1H-py
rroles.