We describe a case of multiple hepatic pyogenic abscesses with an unus
ual presentation. The typical signs and symptoms of fever and pain in
the right upper quadrant were absent. Instead, the chief complaint was
muscle weakness and myalgias accompanied by weight loss. Findings fro
m an ultrasonogram of the abdomen revealed multiple hepatic lesions co
nsistent with metastases. Hence, the initial presumptive diagnosis was
metastatic malignancy with unknown primary tumor. It was only when pu
rulent material was unexpectedly encountered when a needle biopsy was
performed that the true diagnosis of pyogenic liver abscess was recogn
ized. While liver abscess is rare, it should not be forgotten in the d
ifferential diagnosis for multiple hepatic lesions seen on imaging stu
dies.