A TOUCHING CASE OF CHANNEL REGULATION - THE ATP-SENSITIVE K+ CHANNEL

Authors
TUCKER SJ ASHCROFT FM
Citation
Sj. Tucker et Fm. Ashcroft, A TOUCHING CASE OF CHANNEL REGULATION - THE ATP-SENSITIVE K+ CHANNEL, Current opinion in neurobiology, 8(3), 1998, pp. 316-320
Citations number
48
Categorie Soggetti
Neurosciences
Journal title
Current opinion in neurobiology → ACNP
ISSN journal
09594388
Volume
8
Issue
3
Year of publication
1998
Pages
316 - 320
Database
ISI
SICI code
0959-4388(1998)8:3<316:ATCOCR>2.0.ZU;2-F
Abstract
The classical type of K-ATP channel is an octameric (4:4) complex of t wo structurally unrelated subunits, Kir6.2 and SUR. The former serves as an ATP-inhibitable pore, while SUR is a regulatory subunit endowing sensitivity to sulphonylurea and K+ channel opener drugs, and the pot entiatory action of MgADP. Both subunits are required to form a functi onal channel.