THE MODIFIED WILSON MODEL AND PREDICTING DRUG SOLUBILITY IN WATER-COSOLVENT MIXTURES

Applicability of the modified Wilson model for calculating drug solubi lity in water-cosolvent mixtures is presented. The accuracy and predic tability of the model are compared with those of other models which ca lculate solute solubility as a function of the solvent composition, Me an of percent deviations from experimental values are 7.77, 8.70, 9.06 , 10.72, 10.72 and 18.71, for the modified Wilson, double-log exponent ial, general single model, combined nearly ideal binary solvent/Redlic h-Kister, excess free energy and mixture response surface methods, res pectively.