CHANGE IN SERUM-LIPID HYDROPEROXIDES IN THERMAL-INJURY

The concentration of serum lipid hydroperoxides of male rats of the Wi star strain that had received thermal injury on their backs was measur ed by the hemoglobin-methylene blue (Hb-MB) method. The concentration increased significantly 0.5 h after the injury, was higher than that o f the normal level until 5 h, and decreased to the normal concentratio n by 7 h after the injury. The lipid peroxide level measured by the th iobarbituric acid (TBA) method increased up to 5 h after the injury, a nd then maintained at a higher level than normal for 48 h. Thus, the m easurement of the total concentration of serum lipid hydroperoxides by the Hb-MB method is useful to detect lipid peroxidation in the early period after the injury, and serum lipid peroxide level measured by th e TEA method may reflect the progress of systemic dysfunction.