Several areas in molecular astrophysics and astrochemistry can be uniq
uely studied by a large telescope in the 1 - 10 GHz range, despite the
well-known advantages of the mm spectral range. Some atoms and molecu
les can be observed only in the I - 10 GHz region, others are beat obs
erved there, still others have special excitation effects there which
elucidate important collision processes. Many species of most importan
ce to astrochemistry occur in cold cloud cores where low-frequency stu
dies can provide better abundances and high-resolution maps, both of w
hich test chemistry models. Maser theories can be tested in a variety
of species, including OH and CH, and several species as yet undetected
and observable only at 1 - 10 GHz. Reliable abundances of OH and CH i
n translucent clouds, obtainable only at Arecibo, are highly important
to the astrochemistry of many species. Most molecules possessing a Ze
eman effect are best observed in the 1 - 10 GHz region.