CUTTING EDGE - THE EXPRESSION IN-VIVO OF A 2ND ISOFORM OF PT-ALPHA - IMPLICATIONS FOR THE MECHANISM OF PT-ALPHA ACTION

Authors
BARBER DF PASSONI L WEN L GENG LP HAYDAY AC
Citation
Df. Barber et al., CUTTING EDGE - THE EXPRESSION IN-VIVO OF A 2ND ISOFORM OF PT-ALPHA - IMPLICATIONS FOR THE MECHANISM OF PT-ALPHA ACTION, The Journal of immunology (1950), 161(1), 1998, pp. 11-16
Citations number
21
Categorie Soggetti
Immunology
Journal title
The Journal of immunology (1950) → ACNP
ISSN journal
00221767
Volume
161
Issue
1
Year of publication
1998
Pages
11 - 16
Database
ISI
SICI code
0022-1767(1998)161:1<11:CE-TEI>2.0.ZU;2-Q
Abstract
A second isoform of pT alpha, ''pT alpha(b),'' is derived from the pT alpha locus by tissue-specific, alternative splicing, pT alpha(b) is c oexpressed in the thymus with the previously characterized form of pT alpha (which me term pT alpha(a)) and is also expressed in peripheral cells without pT alpha(a), While pT alpha(a) acts to retain most TCR b eta-chains intracellularly, pTa alpha(b) permits higher levels of cell surface TCR beta expression and facilitates signaling from a CD3-TCR beta complex.