COMPARISON OF A SYNTHETIC ANTITHROMBIN III-BINDING PENTASACCHARIDE AND STANDARD HEPARIN AS AN ADJUNCT TO CORONARY THROMBOLYSIS

The effects on alteplase-induced thrombolysis of the synthetic ATIII-b inding pentasaccharide SR90107A/ORG 31540 (synthetic pentasaccharide, SP) and of standard heparin (SH) were compared in a copper coil model of coronary artery thrombosis in 6 groups of 10 dogs. After 1 h of occ lusion, all animals received intravenously alteplase and aspirin, and were randomly assigned to a 2 h infusion of either saline, or one of t wo doses of SH (100 IU/kg bolus plus 50 IU/kg/h infusion, or 200 IU/kg bolus plus 100 IU/kg/h infusion), or one of three doses of SP (100 nm ol/kg bolus plus 50 nmol/kg/h infusion, 200 nmol/kg bolus plus 100 nmo l/kg/h infusion, or 400 nmol/kg bolus plus 200 nmol/kg/h infusion). Co ronary angiography was per formed every 10 min for 4 h. Appropriate do ses of SP and SH enhanced alteplase-induced thrombolysis to a similar extent. In contrast, SP was devoid of any anti-IIa activity or aPTT pr olongation.