EVALUATION OF DETOMIDINE HYDROCHLORIDE, DIAZEPAM AND THIOPENTAL SODIUM COMBINATION ON CARDIOVASCULAR FUNCTION AND HEMODYNAMICS IN SHEEP

The study was performed on six sheep weighing 30-40 kg to evaluate the effect of detomidine, diazepam and thiopental sodium on cardiovascula r function and hemodynamics. The combination was administered I.V. at the rate of 90.8 +/- 8.21 mu g/kg, 0.54 +/- 0.05 mg/kg and 4.4 +/- 1.0 4 mg/kg, respectively. The effective sedation lasted for 135 +/- 7.9 m in, which caused significant hypotension. The ECG changes were type I A-V block in four cases, T-wave elevation in all cases, S-T segment de pression in three cases and ectopic ventricular beat in two cases. Imm ediate fall of 48% in MAP and 61% in 5 min was considered the characte ristic features of cardiovascular effects of these combined compounds. The PaO2, PaCo2, PvO(2) temperature and hemoglobin changed significan tly but other parameters remained unchanged. All reflexes except anal pinch were abolished and there was no response to noise, external stim uli and pin pricks during the effective period. (C) 1998 Elsevier Scie nce B.V. All rights reserved.