THE SHWARTZMAN REACTION IN RABBITS AS A M ODEL FOR PURPURA FULMINANS - RESULTS WITH HUMAN PROTEIN-C

Authors
PICHLER L AUER W SCHWARZ HP
Citation
L. Pichler et al., THE SHWARTZMAN REACTION IN RABBITS AS A M ODEL FOR PURPURA FULMINANS - RESULTS WITH HUMAN PROTEIN-C, Wiener Tierarztliche Monatschrift (1914), 85(2), 1998, pp. 39-42
Citations number
21
Categorie Soggetti
Veterinary Sciences
Journal title
Wiener Tierarztliche Monatschrift (1914) → ACNP
ISSN journal
0043535X
Volume
85
Issue
2
Year of publication
1998
Pages
39 - 42
Database
ISI
SICI code
0043-535X(1998)85:2<39:TSRIRA>2.0.ZU;2-T
Abstract
The skin lesions as elicited by the local Shwartzman reaction in rabbi ts resemble those seen in human purpura fulminans. Human protein C (80 0 IU/kg i.v.; Ceprotin(R), Immune AG, Vienna) as well as activated hum an protein C (400 U/kg i.v.) were able to mitigate skin lesions in rab bits. The Shwartzman reaction is discussed as a predicitive model for purpura fulminans in humans.