ADAPTIVE RESPONSE IN EMBRYOGENESIS - I - DOSE AND TIMING OF RADIATIONFOR REDUCTION OF PRENATAL DEATH AND CONGENITAL-MALFORMATION DURING THE LATE PERIOD OF ORGANOGENESIS
B. Wang et al., ADAPTIVE RESPONSE IN EMBRYOGENESIS - I - DOSE AND TIMING OF RADIATIONFOR REDUCTION OF PRENATAL DEATH AND CONGENITAL-MALFORMATION DURING THE LATE PERIOD OF ORGANOGENESIS, Radiation research, 150(1), 1998, pp. 120-122
Citations number
22
Categorie Soggetti
Biology Miscellaneous","Radiology,Nuclear Medicine & Medical Imaging
An adaptive response was demonstrated during embryogenesis in mice. Wh
ole-body irradiation at a dose of 0-50 cGy was given to condition preg
nant ICR mice on day 9 to day 11 of gestation, Then their whole bodies
were exposed to a challenging dose of 5 Gy on the next day. The numbe
rs of living fetuses, prenatal deaths and living fetuses with external
gross malformations were determined on day 19. A conditioning dose of
30 cGy on day 11 significantly increased the rate of living fetuses a
nd reduced the incidence of congenital malformations induced by a 5-Gy
dose on day 12. This indicates the existence of a critical dose and t
iming for administering a conditioning dose for radioadaptation during
the late period of organogenesis in mice. The possible mechanisms inv
olved are discussed. (C) 1998 by Radiation Research Society.