Extensive, diffuse, epidural spinal cord compression was visualized my
elographically in two dogs presented for rapid development of nonambul
atory tetraparesis and paraplegia, respectively. Purulent fluid contai
ning bacterial organisms was aspirated percutaneously under fluoroscop
ic guidance from the epidural space of each dog. One dog responded poo
rly to aggressive medical therapy, which included installation of an e
pidural lavage and drainage system. Both dogs were euthanized due to t
he severe nature of their disorder and the poor prognosis. Spinal epid
ural empyema (i. e., abscess) is a rare condition in humans and has no
t been reported previously in the veterinary literature. Spinal epidur
al empyema should be considered as a differential diagnosis in dogs pr
esenting with painful myelopathies, especially when accompanied by fev
er.