THE EFFECT OF AGE AND TESTOSTERONE ON THE EXPRESSION OF GLIAL FIBRILLARY ACIDIC PROTEIN IN THE RAT CEREBELLUM

Authors
DAY JR FRANK AT OCALLAGHAN JP JONES BC ANDERSON JE
Citation
Jr. Day et al., THE EFFECT OF AGE AND TESTOSTERONE ON THE EXPRESSION OF GLIAL FIBRILLARY ACIDIC PROTEIN IN THE RAT CEREBELLUM, Experimental neurology, 151(2), 1998, pp. 343-346
Citations number
40
Categorie Soggetti
Neurosciences
Journal title
Experimental neurology → ACNP
ISSN journal
00144886
Volume
151
Issue
2
Year of publication
1998
Pages
343 - 346
Database
ISI
SICI code
0014-4886(1998)151:2<343:TEOAAT>2.0.ZU;2-X
Abstract
Testosterone reversed the age-related increase in glial fibrillary aci dic protein (GFAP) in the male rat cerebellum, a brain region not gene rally associated with gonadal steroid hormone sensitivity. This suppor ts the hypothesis that a decrease in circulating testosterone contribu tes to age-related increase in GFAP. These data also suggest that redu ctions in circulating gonadal steroids during aging could render the b rain more susceptible to neurodegeneration and that hormone replacemen t therapy might have value in neurodegenerative disease intervention. (C) 1998 Academic Press.