SEBACEOUS CARCINOMA OF THE SUBMANDIBULAR-GLAND WITH HIGH-GRADE MALIGNANCY - REPORT OF A CASE

A case of sebaceous carcinoma arising in the left submandibular gland of a 66-year-old man is reported. The clinical and pathological examin ations revealed a carcinoma, which was of salivary gland in origin, wi th regional lymph nodal metastases, Pathological findings showed featu res of high-grade sebaceous carcinoma with spindle myoepitheliomatous differentiation. Neither squamous cell nor duct epithelial-like cell d ifferentiation was noted. Immunohistochemically, tumor cells were posi tive for cytokeratin, S-100 protein and vimentin. Lipid was demonstrat ed in the cytoplasm of the tumor cells, Ultrastructurally, tumor cells contained numerous intracytoplasmic lipid droplets. Myoepitheliomatou s differentiation is rare in sebaceous carcinoma of the salivary gland . Presented is the second reported case of sebaceous carcinoma arising in the submandibular gland.