N,N'-DIISOPROPYL-O-DIPHENYLMETHYL ISOUREA - A MILD AND CONVENIENT ALKYLATING AGENT FOR THE FORMATION OF CEPHALOSPORIN DERIVATIVES

Authors
CHA KH KANG TW LEE HW KIM EN CHOI NH KIM JW HONG CI
Citation
Kh. Cha et al., N,N'-DIISOPROPYL-O-DIPHENYLMETHYL ISOUREA - A MILD AND CONVENIENT ALKYLATING AGENT FOR THE FORMATION OF CEPHALOSPORIN DERIVATIVES, Synthetic communications, 28(12), 1998, pp. 2207-2211
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
28
Issue
12
Year of publication
1998
Pages
2207 - 2211
Database
ISI
SICI code
0039-7911(1998)28:12<2207:NI-AMA>2.0.ZU;2-3
Abstract
N,N'-Diisopropyl-O-diphenylmethyl isourea reacts with cephalosporin-4- carboxylic acid in tetrahydrofuran at room temperature to give the dip henylmethyl (DPM) ester in good yields without isomerization of the do uble bond from C-3 to C-2.