BETA-CYCLODEXTRIN DERIVATIVES AS FLUORESCENCE ENHANCERS OF THE DRUG, HESPERIDIN

Authors
SHUANG SM GUO SY LI L CAI MY PAN JH
Citation
Sm. Shuang et al., BETA-CYCLODEXTRIN DERIVATIVES AS FLUORESCENCE ENHANCERS OF THE DRUG, HESPERIDIN, Analytical letters, 31(8), 1998, pp. 1357-1366
Citations number
17
Categorie Soggetti
Chemistry Analytical
Journal title
Analytical letters → ACNP
ISSN journal
00032719
Volume
31
Issue
8
Year of publication
1998
Pages
1357 - 1366
Database
ISI
SICI code
0003-2719(1998)31:8<1357:BDAFEO>2.0.ZU;2-9
Abstract
The fluorescence behavior of the drug hesperidin in several cyclodextr ins(CDS):beta-cyclodestrin(beta-CD), hydroxypropyl-beta-CD (HP-beta-CD ) and methyl-beta-CD(M-beta-CD) was studied. The stoichiometry of the complexes and their apparent formation constants were estimated. The e xcitation wavelengths were at 335nm for hesperidin in beta-CD,HP-beta- CD and M-beta-CD media. The emission wavelengths were at 444, 436 and 434 nm, respectively; The fluorescence enhancement of hesperidin was o bserved in different cyclodextrin media. The linear calibration plots between fluorescence intensity and hesperidin concentration were deter mined in the 10(-7)similar to 10(-5) M range. The mechanism for the en hanced fluorescence was attributed to protection of the excited state within the cyclodextrin cavity.