GENOTOXICITY OF THE INSECTICIDE ROTENONE IN CULTURED HUMAN-LYMPHOCYTES

Authors
GUADANO A GONZALEZCOLOMA A DELAPENA E
Citation
A. Guadano et al., GENOTOXICITY OF THE INSECTICIDE ROTENONE IN CULTURED HUMAN-LYMPHOCYTES, Mutation research. Genetic toxicology and environmental mutagenesis, 414(1-3), 1998, pp. 1-7
Citations number
16
Categorie Soggetti
Toxicology,"Genetics & Heredity","Biothechnology & Applied Migrobiology
Journal title
Mutation research. Genetic toxicology and environmental mutagenesis → ACNP
ISSN journal
13835718
Volume
414
Issue
1-3
Year of publication
1998
Pages
1 - 7
Database
ISI
SICI code
1383-5718(1998)414:1-3<1:GOTIRI>2.0.ZU;2-4
Abstract
We have investigated the genotoxic activity of rotenone on three genet ic endpoints, sister-chromatid exchanges (SCE), chromosome aberrations (CA) and micronuclei (MN) in human lymphocyte cultures in the presenc e and absence of a metabolic activation system (S9 mix). Our results i ndicate that rotenone increases the frequency of binucleated micronucl eated (BNMN) cells and causes a delay in the cell cycle but does not i ncrease the frequency of CA and SCE at the concentrations used. The pr esence of S9 mix reduces the genotoxic activity of rotenone. (C) 1998 Elsevier Science B.V. All rights reserved.