NEUTROPHILS AND ACUTE ISCHEMIA-REPERFUSION INJURY

Leukocyte infiltration in response to I/R injury is a well-known but p oorly understood phenomenon. The contribution of neutrophils in this p rocess is still controversial. Despite numerous data, little is known about exact numbers of infiltrating neutrophils, The role of monocytes /macrophages in this process is even more unclear. The role neutrophil s in the kidney and other organs was reviewed. The variability in mode ls and methods for neutrophil quantification were examined, along with carrying out a critical overview of depletion and anti-adhesion appro aches. Nevertheless, the exact role attributed to neutrophils in the I /R process remains unclear.