WIKTOR STENT FOR ELECTIVE PLACEMENT WITH ANTIPLATELET REGIME - THE WINE TRIAL

Introduction and objectives. The main problems associated with coronar y stent; implantation are subacute thrombosis and vascular and hemorrh agic complications due to the intensive anticoagulant regime. We studi ed the complications and the six-month restenosis rate after the elect ive implantation of a Wiktor stent in patients treated only with antip latelet drugs. Patients and methods. The WINE study is an open, observ ational, multicenter study that included 368 patients (380 lesions) fr om 11 Spanish hospitals. AU patients were treated with aspirin (125-32 5 mg/day) and ticlopidine (250 mg/12 h for 4 weeks). After hospitaliza tion, a clinical control and clinical and angiographic controls were p erformed at one and six months respectively. Results. 27 patients were excluded after the procedure because of failed delivery of the stent (5 cases), suboptimal angiographic result (15 cases) or lack of adhere nce to the antithrombotic regime (7 cases). Among the 341 patients wit h an adequate result most lesions (76.2%) were type B, including 39.1% type B2 and 8.5% type C. Subacute stent occlusion ocurred in two pati ents (0.6%). Seven patients (2.1%) had vascular complications related to the arterial puncture. No major hemorrhagic complications needing t ransfusion were found. At six months 64 patients (19.8%) showed angiog raphic restenosis. Conclusions. When the angiographic result after Wik tor stent placement is adequate, the therapy with aspirin and ticlopid in is associated with a very low stent thrombosis rate as well as with a low rate of vascular complications and 6 month angiographic resteno sis.