M. Miura et al., FACTORS AFFECTING MANDIBULAR COMPLICATIONS IN LOW-DOSE RATE BRACHYTHERAPY FOR ORAL TONGUE CARCINOMA WITH SPECIAL REFERENCE TO SPACER, International journal of radiation oncology, biology, physics, 41(4), 1998, pp. 763-770
Citations number
27
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
Purpose: To evaluate the efficacy of a spacer in the prevention of man
dibular complications in low dose rate (LDR) brachytherapy (BRT) for o
ral tongue carcinoma. Methods and Materials: A retrospective analysis
was conducted using 103 patients with TI or T2 tongue carcinoma treate
d by a single plane implantation of iridium (Ir-192) pins between 1979
-1994. Of these patients, 60 were treated by BRT alone, and the rest w
ere combined with external irradiation (Ext) and/or chemotherapy (CHT)
. Forty-eight and 55 patients were given BRT with and without a spacer
, respectively. Spacers were individually made of acrylic resin accord
ing to a prosthetic technique so as to obtain the thickness of 7-10 mm
at the lingual part of the implanted side. Variables, including a spa
cer, which may be associated with the development of osteoradionecrosi
s (ORN) of the mandible, were analyzed by the Cox proportional hazards
regression analysis. Results: Our spacer reduced about 50% of the abs
orbed dose at the Lingual side surface of the lower gingiva (LSG) to t
hat in the absence of a spacer. Absolute incidence of ORN was 2.1% (1
of 48) and 40.0% (22 of 55), with and without a spacer, respectively,
and the difference was statistically significant by univariate analysi
s (p 0.0004). It was revealed by the Cox analysis that the spacer (p =
0.0247), combined CHT (p = 0.0295), and combined Ext (p = 0.0279) wer
e significant independent factors associated with the development of O
RN. The spacer was shown to be a significant factor by univariate anal
ysis (p = 0.0037), but not by multivariate analysis when analysis was
restricted to the patients who did not receive CHT. The absorbed dose,
dose rate, and biological effective dose (BED) reflecting early or la
te response mere estimated at the LSG, and prognosticators associated
with the incidence of ORN were also determined by the Cox analysis. Pa
rticularly, BED for late response by BRT, the total absorbed dose, and
any BED by Ext plus BRT were highly significant factors in the whole
population. Essentially similar results were obtained in the patients
without receiving CHT. Conclusions: It was clarified that our spacer e
ffectively prevents mandibular complications in LDR BRT by Ir-192 for
oral tongue carcinoma. Furthermore, introduction of a spacer provided
novel information concerning the development of ORN, where BED particu
larly for late response given by BRT, the total absorbed dose, and any
BED by Ext plus BRT could be good prognostic factors only when estima
ted at the LSG. (C) 1998 Elsevier Science Inc.