NO ASSOCIATION BETWEEN APOLIPOPROTEIN-E ALLELES AND OLIVOPONTOCEREBELLAR ATROPHY

Apolipoprotein E (apo E) epsilon 4 is a risk factor for sporadic and l ate-onset familial Alzheimer's disease, but it is not well known wheth er the apo E is associated with spinocerebellar degeneration. We studi ed the frequency of apo E allele in 59 olivopontocerebellar atrophy (O PCA) patients, including 13 pathologically confirmed cases. The distri bution of the apo E allele frequency did not differ between OPCA patie nts and controls. Apo E allele does not influence the development of O PCA. (C) 1998 Elsevier Science B.V.