PYRIPYROPENES, NOVEL INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY ASPERGILLUS-FUMIGATUS .2. STRUCTURE ELUCIDATION OF PYRIPYROPENE-A, PYRIPYROPENE-B, PYRIPYROPENE-C AND PYRIPYROPENE-D

Authors
KIM YK TOMODA H NISHIDA H SUNAZUKA T OBATA R OMURA S
Citation
Yk. Kim et al., PYRIPYROPENES, NOVEL INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY ASPERGILLUS-FUMIGATUS .2. STRUCTURE ELUCIDATION OF PYRIPYROPENE-A, PYRIPYROPENE-B, PYRIPYROPENE-C AND PYRIPYROPENE-D, Journal of antibiotics, 47(2), 1994, pp. 154-162
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
2
Year of publication
1994
Pages
154 - 162
Database
ISI
SICI code
0021-8820(1994)47:2<154:PNIOA->2.0.ZU;2-0
Abstract
The structures of pyripyropenes A, B, C and D, novel acyl-CoA: cholest erol acyltransferase (ACAT) inhibitors, were determined mainly by spec troscopic studies including various NMR measurements. Pyripyropenes ha ve a common structure which consists of pyridine, alpha-pyrone and ses quiterpene moieties. One of the three O-acetyl residues in the sesquit erpene moiety of pyripyropene A is replaced with an O-propionyl residu e in pyripyropenes B, C and D.