MODIFICATION OF GLYCOPEPTIDE ANTIBIOTIC EREMOMYCIN BY THE ACTION OF ALKYL-HALIDES AND STUDY ON ANTIBACTERIAL ACTIVITY OF THE COMPOUNDS OBTAINED

Alkylation of glycopeptide antibiotic eremomycin by the action of diff erent alkyl halides leads, depending on the structure of alkyl halides used, to eremomycin derivatives of six types; alkylated at the N-term inus, quaternary compounds at the N-terminus, eremomycin esters, ester s of eremocycin alkylated at the N-terminus, eaters of eremomycin quat ernised at the N-terminus, esters of eremomycin alkylated both at the N-terminus and at the aminogroup of disaccharide branch. Five compound s demonstrated high antibacterial activity in vitro, N-allyleremomycin and methyl ester of N,N-dimethyleremomycin being at least as good as the parent eremomycin.