SYNTHESIS, CHARACTERIZATION AND BIODISTRIBUTION OF NEW TC-99M OXO ANDNITRIDO COMPLEXES WITH BIDENDATE AND TETRADENDATE UNSATURATED NS AND N2S2 SCHIFF-BASES DERIVED FROM 2-AMINOCYCLOPENTENE-1-DITHIOCARBOXYLIC ACID AS POTENTIAL HEART IMAGING AGENTS

The synthesis, characterization and Tc-99m labelling of unsaturated di amino dithiol ligands with methyl dithiocarboxylate functions: 2-amino cyclopentene-1-dithiocarboxylic methyl ester (H(2)L1), N,N'-ethylene b is (methyl 2-aminocyclopentene-1-dithiocarboxylate) (H(2)L2) and N,N'- propylene bis (methyl 2-aminocyclopentene-1-dithiocarboxylate) (H(2)L3 ) are described. Cationic oxo (Tc=0) and neutral nitrido (Tc=N) comple xes were obtained. Biodistribution studies in rat showed a good heart uptake of (TcN)-Tc-99m-L2 (2% ID at 5 min) with a high heart-to-blood ratio (5.8 at 5 min), but this complex also exhibited high lung and li ver uptake.