EXPOSURE TO GLYCOLS AND THEIR RENAL EFFECTS IN MOTOR SERVICING WORKERS

Ten car mechanics frequently exposed to glycol-based cooling liquids w ere followed during a workshift. Airborne ethylene and propylene glyco l concentrations in the car mechanics' environment were measured; The car mechanics gave urine samples after the workshift and their excreti on of ethylene glycol, propylene glycol, oxalic acid, calcium and ammo nia was analysed and compared to that of unexposed office workers. Uri nary succinate dehydrogenase activity and glycosaminoglycans were also measured in both groups. Airborne ethylene and propylene glycol conce ntrations in the car mechanics' environment were negligible. Urinary e thylene glycol excretion in exposed workers was significantly higher t han that in unexposed workers, but propylene glycol excretion was at t he same level as in controls. In the exposed group, the excretion of t he end metabolite of ethylene glycol, oxalic acid (47 +/- 11 mmol/mol creatinine, mean +/- SD, n = 10) differed slightly from that of contro ls (36 +/- 14 mmol/mol creatinine, mean +/- SD, n = 10). Urinary excre tion of ammonia was higher among exposed workers than office workers. The excretion of calcium did not differ from that of controls. A margi nally decreased urinary succinate dehydrogenase activity was found in the exposed men. The excretion of glycosaminoglycans was significantly lower in exposed workers. Therefore, it seems that ethylene glycol is absorbed by skin contact. The internal body burden is associated with oxaluria and increased ammoniagenesis typical of chronic acidosis.