ANTITHROMBOTIC EFFECTS OF YM-60828 IN 3 THROMBOSIS MODELS IN GUINEA-PIGS

The antithrombotic effects of a novel factor Xa inhibitor, YM-60828 ([ cetimidoyl-4-piperidyl)oxy]phenyl]-N-[7-amidino-2- naphthyl)methyl]su lfamoyl]acetic acid dihydrochloride), in three thrombosis models in gu inea pigs were studied in comparison with its effect on bleeding time. The antithrombotic effects of YM-60828 were most pronounced in the ve nous thrombosis and the arterio-venous shunt models but YM-60828 showe d l0-fold weaker effects in the carotid thrombosis model. However, YM- 60828 prolonged bleeding time at a much higher dose than that required in all thrombosis models. In conclusion, YM-60828 exerted its antithr ombotic effects without prolonging bleeding time in all thrombosis mod els and may be of clinical value not only in venous thrombosis but als o in arterial thrombosis. (C) 1998 Elsevier Science B.V. All rights re served.