Pulmonary tumor embolism is an often missed antemortem diagnosis in pa
tients with cancer and respiratory failure. Although rare, this compli
cation is an important cause of additional morbidity. Referred for rad
ionuclide pulmonary perfusion and ventilation scintigraphy, a typical
pattern of multiple subsegmental peripheral defects on perfusion lung
scanning without matching ventilation defects, suggesting a high proba
bility for pulmonary thromboembolism, often leads to false conclusions
. We present a case of bilateral multiple subsegmental mismatched defe
cts in lung ventilation perfusion scintigraphy, where autopsy confirme
d the diagnosis of pulmonary tumor embolism, secondary to an undiffere
ntiated ductal type adenocarcinoma of the pancreas. Pulmonary tumor em
bolism is an entity to keep in mind in patients treated for carcinoma
presenting with (sub) acute dyspnea.