INCORPORATION OF METHYLATED PYRIMIDINE ANALOGS INTO RNA

Authors
VYLE JS YOUNG KJ GRASBY JA
Citation
Js. Vyle et al., INCORPORATION OF METHYLATED PYRIMIDINE ANALOGS INTO RNA, Tetrahedron letters, 39(28), 1998, pp. 5093-5096
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
28
Year of publication
1998
Pages
5093 - 5096
Database
ISI
SICI code
0040-4039(1998)39:28<5093:IOMPAI>2.0.ZU;2-Z
Abstract
Routes for the preparation of 2'-silyl protected phosphoramidites of t he modified nucleosides O-2-methyluridine and O-4-methyluridine are de scribed. Methodology for the site-specific incorporation of these phos phoramidites into a 25 nucleotide long oligoribonucleotide sequence by solid-phase synthesis is reported. (C) 1998 Elsevier Science Ltd. All rights reserved.