SIMPLE FRAGMENT SYNTHESES OF ALL 4 ISOMERS OF THE SPERMINE ALKALOID KUKOAMINE

Authors
KARIGIANNIS G MAMOS P BALAYIANNIS G KATSOULIS I PAPAIOANNOU D
Citation
G. Karigiannis et al., SIMPLE FRAGMENT SYNTHESES OF ALL 4 ISOMERS OF THE SPERMINE ALKALOID KUKOAMINE, Tetrahedron letters, 39(28), 1998, pp. 5117-5120
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
28
Year of publication
1998
Pages
5117 - 5120
Database
ISI
SICI code
0040-4039(1998)39:28<5117:SFSOA4>2.0.ZU;2-#
Abstract
All four isomers of the spermine alkaloid kukoamine were unambiguously prepared through diacylation with O.O'-dibenzylcaffeyl chloride of su itably protected (benzyl and/or trityl groups) spermine derivatives, a ssembled on solid and/or in liquid phase using (beta-alanine and gamma -aminobutyric acid, followed by simultaneous N- and O deprotection and double bond reduction using catalytic hydrogenation. (C) 1998 Elsevie r Science Ltd. All rights reserved.