Jl. Jones et al., TRENDS IN AIDS-RELATED OPPORTUNISTIC INFECTIONS AMONG MEN WHO HAVE SEX WITH MEN AND AMONG INJECTING DRUG-USERS, 1991-1996, The Journal of infectious diseases, 178(1), 1998, pp. 114-120
Incidence trends for the 13 most frequent AIDS-defining opportunistic
infections (OIs) among men who have sex with men (MSM, n = 15,588) and
injecting drug users (IDUs, n = 4475) were examined using data abstra
cted from medical records in >90 hospitals and clinics in nine US citi
es during 1991-1996, Among MSM, the most frequent OIs were Mycobacteri
um avium complex (MAC) disease, Pneumocystis carinii pneumonia (PCP),
and cytomegalovirus (CMV) retinitis; decreasing (P less than or equal
to.05) trends occurred for 11 OIs (MAC disease, PCP, CMV retinitis, Ka
posi's sarcoma, esophageal candidiasis, CMV disease, extrapulmonary cr
yptococcosis, toxoplasmic encephalitis, tuberculosis, chronic herpes s
implex, and disseminated histoplasmosis). Among IDUs, the most frequen
t OIs were PCP, MAC disease, and esophageal candidiasis; decreasing tr
ends occurred for 5 OIs (PCP, esophageal candidiasis, tuberculosis, ch
ronic herpes simplex, and chronic cryptosporidiosis) and an increase o
ccurred in recurrent pneumonia. The differences in trends for MSM and
IDUs may be due to differences in medical fare and adherence to preven
tive medications.