MAGNESIUM-SULFATE INTRAUTERINE THERAPY IN THE MARE

A study was conducted to investigate the effect of magnesium sulfate s olution on the equine endometrium using 7 treatment mares and 3 contro l mares. Treatment mares were infused with 128 grams of magnesium sulf ate in one liter of 0.9% sodium chloride, while control mares were inf used with one liter of 0.9% sodium chloride. Reproductive examinations , including palpation and ultrasound examination per rectum of interna l genitalia, vaginoscopy, uterine culture, uterine cytology, endometri al biopsy, and hysteroscopy, were performed 12 days prior to infusion and days 1, 7 and 21 after infusion, Serum magnesium concentrations we re assessed at 0, 1, 2, 4, 6, and 12 hours post-infusion. The only sta tistically significant findings in assessed reproductive parameters wa s a more cloudy vaginal discharge and a higher biopsy score in control mares on day 1 post-infusion. These findings were not present at the day 7 or 21 observation periods. This study demonstrates that intraute rine magnesium sulfate, used at the concentration described, did not r esult in harmful effects detectable by the parameters evaluated. It sh ould be noted that assessment of the effect of magnesium sulfate on sp ecific uterine pathologies or fertility was not made.