After 25 years, there is enough clinical outcome experience to determi
ne appropriate use of home parenteral nutrition in different disease s
tates and age groups. Information regarding how to avoid complications
and how patients and families can find necessary psychosocial support
is provided in this article. Currently, small bowel transplantation i
s not a safer choice, unless there is severe liver disease caused by h
ome parenteral nutrition or lack of central intravenous access.