A GENE FOR RECESSIVE NONSYNDROMIC SENSORINEURAL DEAFNESS (DFNB18) MAPS TO THE CHROMOSOMAL REGION 11P14-P15.1 CONTAINING THE USHER-SYNDROME TYPE 1C GENE

Authors
JAIN PK LALWANI AK LI XC SINGLETON TL SMITH TN CHEN A DESHMUKH D VERMA IC SMITH RJH WILCOX ER
Citation
Pk. Jain et al., A GENE FOR RECESSIVE NONSYNDROMIC SENSORINEURAL DEAFNESS (DFNB18) MAPS TO THE CHROMOSOMAL REGION 11P14-P15.1 CONTAINING THE USHER-SYNDROME TYPE 1C GENE, Genomics, 50(2), 1998, pp. 290-292
Citations number
15
Categorie Soggetti
Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
Genomics → ACNP
ISSN journal
08887543
Volume
50
Issue
2
Year of publication
1998
Pages
290 - 292
Database
ISI
SICI code
0888-7543(1998)50:2<290:AGFRNS>2.0.ZU;2-7
Abstract
Autosomal recessive nonsyndromic sensorineural deafness segregating in a large consanguineous Indian family was mapped to chromosome 11p14-p 15.1 defining a new locus, DFNB18. A maximum lad scope of 4.4 at Theta = 0 was obtained for the polymorphic microsatellite marker D11S1888. Haplotype analysis localizes this gene between markers D11S1307 and D1 1S2368, which is approximately 1.6 cM and encompasses the region of Us her syndrome type 1C (USHP1C). We postulate that DFNB18 and USH1C are allelic variants of the same gene. (C) 1998 Academic Press.