HAEMATOPATHOLOGY OF MICE IN ACUTE EXPERIMENTAL EDWARDSIELLOSIS

In experimentally induced edwardsiellosis in mice pathogenesis study w as conducted. Edwardsiella tarda infection in mice after inoculation o f LD50 dose intraperitoneally, caused increase in clotting timi: (20-2 5 min) and haemoconcentration. Total erythrocyte count and leucocyte c ount dropped down within first 12 hr of infection then rose steadly. D ifferential leucocyte count depicted specific pattern. Gross as well a s histopathological lesions corresponding to acute vasculitis were obs erved apart from desquamative gastroenteritis. Focal mononuclear cell infiltration were evident in hepatic lobules, renal medulla, interalve olar septa and serosa-submucosa of glandular stomach and upper small i ntestine.