PRIMARY SCLEROSING CHOLANGITIS WITH AUTOIMMUNE HEMOLYTIC-ANEMIA AND PULMONARY INFILTRATIONS

A 39-year-old man presenting with pulmonary infiltrations and hemolyti c anemia was diagnosed as having primary sclerosing cholangitis (PSC) without evidence of ulcerative colitis. This constellation of associat ions is unique to the best of our knowledge. Autoimmune hemolytic anem ia has been reported to be associated with PSC on only a few occasions , and pulmonary infiltrations in association with PSC are also quite u nusual. Genetic and immunologic mechanisms are major factors in the pa thogenesis of these disorders.