REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF THE COMPONENTS OF GASOLINE

The reproductive, developmental, and postnatal toxicity of 14 select c hemicals and mixtures that are components of gasoline has been reviewe d. The majority of experimental analyses have been performed as either variations of the accepted segment 2 protocol or as traditional terat ology studies. Specific deficiencies in the present database have been identified and are most obvious in the evaluation of reproductive and postnatal effects. It is recommended that future studies address the continuing need for assessment in multiple species and over a range of dosages with specific emphasis on the impact of route of administrati on on the results obtained.